Schmidt-Westhausen A, Becker J, Schuppan D, Burkhardt A, Reichart P A
Humboldt-Universität zu Berlin, Universitätsklinikum Charité, Abteilung für Oralchirurgie und Zahnärztliche Röntgenologie, Germany.
Eur J Cancer B Oral Oncol. 1994 Nov;30B(6):377-80. doi: 10.1016/0964-1955(94)90015-9.
In order to elucidate the origin of the odontogenic myxoma, the composition and the structural organisation of the extracellular matrix (ECM) of this tumour were characterised. Collagen type I, VI, procollagen type III, undulin, tenascin and fibronectin were demonstrated in biopsy material of 4 cases by polyclonal antibodies. The tumour stroma showed a pronounced reaction for collagen type I. Fibroblasts displayed an intense intracytoplasmatic reaction for procollagen type III, and collagen type I was not found in the fibroblasts of the adjacent normal oral mucosa. In contrast to the surrounding connective tissue, label for collagen type VI was weak, as was the reaction for fibronectin and tenascin. Undulin was almost undetectable. The immunohistochemical results suggest that the odontogenic myxoma is characterised by an as yet unobserved structural organisation of ECM proteins, a secretion defect of fibrillar collagens type I and III with no resemblance to physiological tooth development.
为了阐明牙源性黏液瘤的起源，对该肿瘤细胞外基质（ECM）的组成和结构组织进行了表征。通过多克隆抗体在4例活检材料中检测到了I型、VI型胶原蛋白、III型前胶原蛋白、内联蛋白、腱生蛋白和纤连蛋白。肿瘤基质对I型胶原显示出明显反应。成纤维细胞对III型前胶原表现出强烈的胞浆内反应，而在相邻正常口腔黏膜的成纤维细胞中未发现I型胶原。与周围结缔组织相比，VI型胶原的标记较弱，纤连蛋白和腱生蛋白的反应也较弱。内联蛋白几乎无法检测到。免疫组织化学结果表明，牙源性黏液瘤的特征在于ECM蛋白尚未观察到的结构组织、I型和III型纤维状胶原蛋白的分泌缺陷，与生理性牙齿发育无关。
