Barton A L, Banner B F, Cable E E, Bonkovsky H L
Department of Pathology, University of Massachusetts Medical Center, Worcester 01655-0125, USA.
Am J Clin Pathol. 1995 Apr;103(4):419-24. doi: 10.1093/ajcp/103.4.419.
Recent evidence suggests that patients with chronic hepatitis C virus (CHCV) who respond to interferon-alpha (IFN) therapy have a lower hepatic iron concentration than those who do not. The object of this study was to assess the concentration and distribution of iron in liver biopsies from 15 patients with CHCV seen at the authors' medical center between June 1992 and March 1993. Patients with complete response to IFN were compared to those with non-complete response with respect to quantitative hepatic iron concentration, serum iron indices, and a detailed analysis of histologic features of hematoxylin-and-eosin and iron-stained pre-IFN biopsies. Patients with non-complete response had significantly higher scores for stainable iron in sinusoidal cells (P = .02) and portal tracts (P = .05) than did patients with complete response. Total hepatic iron scores, mean quantitative hepatic iron, and mean serum ferritin were higher in patients with noncomplete response, but the differences were not significant. In conclusion, iron deposition in sinusoidal cells and portal tracts is significantly less frequent in patients with complete response to IFN than in those with poor or no response, and may be a useful, objective predictor of response to IFN therapy.
最近有证据表明，对α干扰素（IFN）治疗有反应的慢性丙型肝炎病毒（CHCV）患者的肝脏铁浓度低于无反应者。本研究的目的是评估1992年6月至1993年3月在作者所在医疗中心就诊的15例CHCV患者肝活检中铁的浓度和分布情况。将对IFN完全反应的患者与未完全反应的患者在肝脏铁定量浓度、血清铁指标以及对苏木精-伊红染色和铁染色的IFN治疗前活检组织学特征进行详细分析方面进行比较。未完全反应的患者在窦状隙细胞（P = 0.02）和汇管区（P = 0.05）中可染色铁的评分显著高于完全反应的患者。未完全反应患者的肝脏总铁评分、平均肝脏铁定量和平均血清铁蛋白较高，但差异不显著。总之，对IFN完全反应的患者窦状隙细胞和汇管区的铁沉积频率明显低于反应不佳或无反应的患者，可能是IFN治疗反应的一个有用的客观预测指标。
