干扰素诱导的PKR的调控：病毒能应对吗？
Regulation of the interferon-induced PKR: can viruses cope?
作者信息
Katze M G
机构信息
Dept of Microbiology, School of Medicine, University of Washington, Seattle 98195, USA.
出版信息
Trends Microbiol. 1995 Feb;3(2):75-8. doi: 10.1016/s0966-842x(00)88880-0.
PMID:7537157
Abstract
Viruses that fail to block the lethal effects of the double-stranded-RNA-activated protein kinase (PKR) may be doomed; why do so many viruses go to so much trouble to downregulate this interferon-induced protein kinase? PKR may regulate cell growth and proliferation in uninfected cells, suggesting that it also participates in the antiproliferative arm of the interferon response.
摘要
无法阻断双链RNA激活蛋白激酶（PKR）致死效应的病毒可能注定灭亡；为何如此多病毒要不遗余力地下调这种干扰素诱导的蛋白激酶呢？PKR可能在未感染细胞中调节细胞生长和增殖，这表明它也参与了干扰素反应的抗增殖环节。
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