Ichikawa S, Sreedharan S P, Owen R L, Goetzl E J
Department of Anatomy, Tokyo Medical College, Japan.
Am J Physiol. 1995 Apr;268(4 Pt 1):L584-8. doi: 10.1152/ajplung.1995.268.4.L584.
Peptidergic nerves in the respiratory tract release vasoactive intestinal peptide (VIP) and substance P (SP), which mediate physiological and immune functions. Antipeptide antibodies to type I VIP receptor (VIPR) and NK-1-type SP receptor (SPR) were used to identify these receptors in normal rat lungs. VIPRs and SPRs were detected on airway epithelium from the trachea to the respiratory bronchioles but not in alveoli, submucosal glands, or pulmonary smooth muscle, except for that of some pulmonary veins. VIPRs also were expressed on macrophages around capillaries, in tracheal and bronchial connective tissue, in alveolar walls, and in the subintima of pulmonary veins and some arterioles. The absence of receptors from airway smooth muscle and submucosal glands implies that mediation of some known effects of SP and VIP may be epithelial or macrophage dependent. Other types of VIPRs and SPRs on airway glands and smooth muscle may transduce direct effects. The similar localization of VIPRs and SPRs in rat lung suggests that VIP and SP may coordinately regulate some pulmonary functions.
呼吸道中的肽能神经释放血管活性肠肽（VIP）和P物质（SP），它们介导生理和免疫功能。利用抗I型VIP受体（VIPR）和NK-1型SP受体（SPR）的抗肽抗体在正常大鼠肺中鉴定这些受体。在从气管到呼吸细支气管的气道上皮细胞上检测到VIPR和SPR，但在肺泡、黏膜下腺或肺平滑肌中未检测到，除了一些肺静脉的平滑肌。VIPR也表达于毛细血管周围的巨噬细胞、气管和支气管结缔组织、肺泡壁以及肺静脉和一些小动脉的内膜下。气道平滑肌和黏膜下腺中缺乏受体意味着SP和VIP的一些已知作用可能依赖于上皮细胞或巨噬细胞介导。气道腺体和平滑肌上的其他类型的VIPR和SPR可能传导直接作用。大鼠肺中VIPR和SPR的相似定位表明VIP和SP可能协同调节某些肺功能。
