Iakovenko L F, Spivak N Ia, Ganova L A, Krivokhatskaia L D, Mazalevskiĭ A F, Radchenko N A, Ershov F I
Antibiot Khimioter. 1994 Nov;39(11):48-52.
Impairments in the interferon status of children with chronic and recurring diseases of the respiratory organs were investigated and its correction was shown possible with the use of alpha 2-interferon (reaferon). Suppression of the interferon-producing capacity of the immunocytes was observed in all the cases of the disease aggravation. The level of the suppression correlated with the severity of the infection. In the patients affected by radiation the suppression of the interferonogenesis was more marked. However, in these cases no dependence of the detected impairments in the interferon status on the level of the radiation pollution of the territory of the children residence was shown. The inclusion of reaferon to the basal therapy resulted in a significant increase of the alpha-interferon production in the cases of bronchial asthma and asthmatic bronchitis as well as its recovery to the normal in the cases of recurring bronchitis and chronic pneumonia. In all the cases of bronchopulmonary diseases only a tendency towards normalization of the alpha-interferon indices was recorded.
对患有慢性和复发性呼吸器官疾病的儿童的干扰素状态损伤进行了研究，并表明使用α2干扰素（重组干扰素）可以对其进行纠正。在疾病加重的所有病例中均观察到免疫细胞产生干扰素能力的抑制。抑制水平与感染的严重程度相关。在受辐射影响的患者中，干扰素生成的抑制更为明显。然而，在这些病例中，未显示所检测到的干扰素状态损伤与儿童居住地区辐射污染水平之间的相关性。在基础治疗中加入重组干扰素，在支气管哮喘和喘息性支气管炎病例中导致α干扰素产生显著增加，在复发性支气管炎和慢性肺炎病例中使其恢复正常。在所有支气管肺部疾病病例中，仅记录到α干扰素指标有趋于正常的趋势。
