Kohase M
Department of Viral Disease and Vaccine Control National Institute of Health Japan, Musashimurayama.
Rinsho Byori. 1995 Apr;43(4):324-8.
Expert committee on Biological standardization (ECBS) of WHO had asked for an advisory committee for preparation of WHO international cytokine standards because of complexities by the rapid increase of number of cytokine molecules some of which are entered into clinical trials. The new meeting of the WHO informal Consultation on Cytokine standards was started from last spring and going to be held annually. The main mission of the committee was considered to be promoting the use of WHO international cytokine standards and reference materials etc., which must be available world wide. Various standard preparations of cytokines and growth factors are available at the National Institute of Biological Standards and Control (NIBSC) in the United Kingdom, some of which have been accepted by WHO as international standards (Table 1). Japanese national standards which had been prepared before establishment of WHO standards, and being labeled as Japanese reference Units (JRU) have to be calibrated with WHO standards to know International Units (IU). Japanese national references of IL-2 and TNF alpha were calibrated by collaboration with related companies and NIH Japan and the concluded results are obtained as follows. IL-2 (rec. DNA):1JRU = 1 IU TNF alpha (rec. DNA):1JRU = 35 IU
世界卫生组织生物标准化专家委员会（ECBS）因细胞因子分子数量迅速增加带来的复杂性（其中一些已进入临床试验），要求成立一个咨询委员会来制定世界卫生组织国际细胞因子标准。世界卫生组织细胞因子标准非正式磋商会的新会议从去年春天开始，今后将每年举行。该委员会的主要任务被认为是促进世界卫生组织国际细胞因子标准和参考物质等的使用，这些标准和物质必须在全球范围内可用。英国国家生物标准与控制研究所（NIBSC）提供了各种细胞因子和生长因子的标准制剂，其中一些已被世界卫生组织接受为国际标准（表1）。在世卫组织标准制定之前就已制定的日本国家标准，标注为日本参考单位（JRU），必须与世界卫生组织标准进行校准，以确定国际单位（IU）。通过与相关公司和日本国立卫生研究院合作，对日本的白细胞介素-2和肿瘤坏死因子α国家参考品进行了校准，得出以下结果。白细胞介素-2（重组DNA）：1JRU = 1IU；肿瘤坏死因子α（重组DNA）：1JRU = 35IU
