Zaugg P Y, Bernardi M, Schmid M, Havelka J, Bühler H
Medizinische Klinik, Stadtspital Waid, Zürich.
Schweiz Med Wochenschr. 1995 Apr 15;125(15):719-22.
The purpose of our study was to verify the correlation between biochemical and histological inflammatory activity in chronic hepatitis C. The histological activity index (HAI) of 42 patients with chronic hepatitis C was correlated with their transaminase activity. There was indeed a significant correlation between histological activity and the AST (r = 0.54, p = 0.0002) and ALT level (r = 0.36, p = 0.018) respectively. Due to considerable scatter of the results, transaminase activity did not allow reliable assessment of inflammatory activity in individual cases. In the majority, markedly elevated transaminase activity was associated with marked histological inflammatory activity, whereas normal or slightly elevated transaminase activity was found in all stages of inflammatory activity. To assess inflammatory activity in chronic hepatitis C, a liberal indication for liver biopsy should therefore be adopted.
我们研究的目的是验证慢性丙型肝炎中生化炎症活动与组织学炎症活动之间的相关性。42例慢性丙型肝炎患者的组织学活动指数（HAI）与他们的转氨酶活性相关。组织学活动与AST（r = 0.54，p = 0.0002）和ALT水平（r = 0.36，p = 0.018）之间确实分别存在显著相关性。由于结果存在相当大的离散性，转氨酶活性无法在个体病例中可靠地评估炎症活动。在大多数情况下，转氨酶活性显著升高与显著的组织学炎症活动相关，而在炎症活动的所有阶段均发现转氨酶活性正常或略有升高。因此，为评估慢性丙型肝炎的炎症活动，应采用较为宽松的肝活检指征。
