Pelley R J
Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, OH 44195, USA.
Semin Oncol. 1995 Apr;22(2 Suppl 3):45-52.
In 1994, more than 200,000 patients in the United States were diagnosed with colon, gastric, or pancreatic cancer. Over half of these patients eventually will have recurrent, incurable disease and require palliative therapy. Although chemotherapy has no role in the primary treatment of most gastrointestinal cancers, and only a limited role as a form of adjuvant treatment in colon cancer, it is sometimes the only systemic treatment available for palliation. Effective chemotherapeutic agents for gastrointestinal cancers are few, and after more than three decades of research, 5-fluorouracil remains one of the few useful agents. This article reviews the role of chemotherapy in palliative therapy for the common gastrointestinal cancers. Discussion also includes recent advances in modulating 5-fluorouracil activity and the many attempts to study newer agents.
1994年，美国有超过20万名患者被诊断患有结肠癌、胃癌或胰腺癌。这些患者中超过一半最终会出现复发且无法治愈的疾病，需要进行姑息治疗。尽管化疗在大多数胃肠道癌症的初始治疗中没有作用，在结肠癌的辅助治疗中作用也有限，但它有时是唯一可用于姑息治疗的全身治疗方法。用于胃肠道癌症的有效化疗药物很少，经过三十多年的研究，5-氟尿嘧啶仍然是少数几种有用的药物之一。本文综述了化疗在常见胃肠道癌症姑息治疗中的作用。讨论还包括调节5-氟尿嘧啶活性的最新进展以及对新型药物的诸多研究尝试。
