乙醇对配体门控离子通道作用的神经解剖学特异性：一种假说。
The neuroanatomical specificity of ethanol action on ligand-gated ion channels: a hypothesis.
作者信息
Breese G R, Morrow A L, Simson P E, Criswell H E, McCown T J, Duncan G E, Keir W J
机构信息
Brain and Development Research Center, University of North Carolina at Chapel Hill 27599, USA.
出版信息
Alcohol Alcohol Suppl. 1993;2:309-13.
PMID:7538301
Abstract
The studies described will demonstrate that the subunit composition of a GABAA receptor allows ethanol to enhance responses to GABA. Since we have determined that ethanol will influence responses to glycine, nicotine and NMDA in some, but not all, neurons with receptors to these agonists, we hypothesize that specific receptor subtypes of these ligand-gated ion channels will be affected by ethanol.
摘要
所描述的研究将证明，GABAA受体的亚基组成使乙醇能够增强对GABA的反应。由于我们已经确定乙醇会影响某些（但不是所有）具有这些激动剂受体的神经元对甘氨酸、尼古丁和NMDA的反应，我们推测这些配体门控离子通道的特定受体亚型将受到乙醇的影响。
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