Lansdorp P M, Dragowska W, Thomas T E, Little M T, Mayani H
Terry Fox Laboratory for Hematology/Oncology, British Columbia Cancer Agency, Vancouver, Canada.
Blood Cells. 1994;20(2-3):376-80; discussion 380-1.
Recent studies in our laboratory have shown striking differences in the functional properties of candidate hematopoietic stem cells purified from fetal, neonatal, and adult human tissues. These differences include the ability to produce CD34+ cells, the turnover rate, and the fraction of cells that respond to a mixture of cytokines. All these parameters decrease with the age of the cell donor, and some of these observations are summarized here. Extensive qualitative changes in hematopoietic cells from various stages of development should be taken into account in the design of novel therapeutic strategies.
我们实验室最近的研究表明，从胎儿、新生儿和成人组织中纯化出的候选造血干细胞在功能特性上存在显著差异。这些差异包括产生CD34+细胞的能力、周转率以及对细胞因子混合物作出反应的细胞比例。所有这些参数都随着细胞供体年龄的增长而降低，这里总结了其中一些观察结果。在设计新的治疗策略时，应考虑到造血细胞在不同发育阶段的广泛质性变化。
