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Ex vivo expansion of cord blood-derived stem cells and progenitors.

作者信息

Moore M A, Hoskins I

机构信息

Developmental Hematopoiesis Laboratory, Sloan-Kettering Institute for Cancer Research, New York, New York, USA.

出版信息

Blood Cells. 1994;20(2-3):468-79; discussion 479-81.

PMID:7538352
Abstract

Cord blood-derived CD34+ cells have proved superior to adult marrow or elicited peripheral blood in ex vivo cell and progenitor expansion. In addition, cord blood-derived cells with a phenotype and function of early stem cells (e.g., long-term culture-initiating cells) can be expanded in vitro in the presence of a combination of cytokines by 15- to 20-fold over 7-14 days. These observations suggest that ex vivo expansion of cord blood CD34+ cells will permit improved engraftment of adults and will prove effective in retroviral-mediated gene transfection of early stem cell populations.

摘要

相似文献

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Ex vivo expansion of cord blood-derived stem cells and progenitors.
Blood Cells. 1994;20(2-3):468-79; discussion 479-81.
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