Zaroli A, Mandressi A, Belloni M, Antonelli D, Bernasconi S, Buizza C, Chisena S
U.O. di Urologia, U.S.S.L. n. 8, Busto Arsizio.
Arch Ital Urol Androl. 1995 Feb;67(1):13-6.
The underlying BPH related mechanisms of outlet obstruction are outlined (modification of the shape of the bladder neck, failure of funnel formation, geometric variations of the urethra, alpha 1 adrenoceptors mediated sympathetic hyperactivity at the level of the lower genito-urinary tract). Bladder voiding dysfunction in response to prostate obstruction is also discussed and correlated to ultrastructural patterns and clinical symptoms. Finally, a pathogenetic mechanism for detrusor overactivity in obstructed bladder is suggested.
