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Isolation and partial characterization of a protease involved in Fas-induced apoptosis.

作者信息

Schlegel J, Peters I, Orrenius S

机构信息

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

出版信息

FEBS Lett. 1995 May 8;364(2):139-42. doi: 10.1016/0014-5793(95)00374-i.

DOI:10.1016/0014-5793(95)00374-i
PMID:7538470
Abstract

Protease involvement has been implicated in the signalling process of activation-induced apoptosis. Here we report the isolation of a protease from Jurkat T cells undergoing Fas-induced apoptosis. Although the protease probably is a serine protease, it seems to be distantly related to members of the ICE/ced-3/Ich-1(nedd-2) family. In a cell-free system using isolated thymocyte nuclei, the protease rapidly induces DNA fragmentation and morphological changes typically seen in apoptosis. Our results clearly show protease activation downstream to Fas-ligation and implicate an important role for the isolated protease in signalling of Fas-induced apoptosis.

摘要

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