Amer M, Mostafa F F, Nasr A N, el-Harras M
Department of Dermatology, University of Zagazig, Faculty of Medicine, Egypt.
Int J Dermatol. 1995 Mar;34(3):186-9. doi: 10.1111/j.1365-4362.1995.tb01564.x.
The purpose of this study was to recognize the role of mast cells in the pathogenesis of scabies.
One hundred and fifty patients and 10 controls were included in the study. Group 1 included 20 patients without previous treatment. In group 2, 80 patients were treated with antiscabietic drugs. Group 3 had 50 patients who received an antiscabietic drug followed by 3 days of crotamiton. Diurnal and nocturnal skin biopsies were taken from group 1. In groups 2 and 3, the biopsies were taken after 2 weeks of treatment. Sections were cut and stained by hematoxylin and eosin and Giemsa stains.
Mast cells were increased in diurnal and nocturnal biopsies. Evident degranulation of mast cells was detected in nocturnal biopsies. The mast cell number decreased to half its pretreatment number in patients treated with antiscabietic drugs and to its normal number in patients treated with antiscabietic drugs followed by 3 days with crotamiton.
The number of mast cells are increased in scabietic lesions. This plays a role in the pathogenesis of the clinical and histologic picture of scabies. We recommend that an antiscabietic drug should be followed by 3 days of crotamiton in the treatment of scabies.
本研究旨在明确肥大细胞在疥疮发病机制中的作用。
本研究纳入了150例患者和10例对照。第1组包括20例未经治疗的患者。第2组，80例患者接受抗疥疮药物治疗。第3组有50例患者先接受抗疥疮药物治疗，随后使用克罗米通3天。对第1组患者进行日间和夜间皮肤活检。第2组和第3组在治疗2周后进行活检。切片经苏木精-伊红染色和吉姆萨染色。
日间和夜间活检中肥大细胞均增多。在夜间活检中检测到肥大细胞明显脱颗粒。接受抗疥疮药物治疗的患者，肥大细胞数量降至治疗前数量的一半；先接受抗疥疮药物治疗随后使用克罗米通3天的患者，肥大细胞数量降至正常水平。
疥疮皮损中肥大细胞数量增加。这在疥疮临床和组织学表现的发病机制中起作用。我们建议在疥疮治疗中，使用抗疥疮药物后应接着使用3天克罗米通。
