在HER-2/neu转染的人肺癌细胞中，通过提高p185neu水平增强化学抗性。 - Suppr

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超能文献

Enhanced chemoresistance by elevation of p185neu levels in HER-2/neu-transfected human lung cancer cells.

作者信息

Tsai C M, Yu D, Chang K T, Wu L H, Perng R P, Ibrahim N K, Hung M C

机构信息

Chest Department, Veterans General Hospital-Taipei, Taiwan.

出版信息

J Natl Cancer Inst. 1995 May 3;87(9):682-4. doi: 10.1093/jnci/87.9.682.

DOI:10.1093/jnci/87.9.682

PMID:7538595

Abstract

摘要

相似文献

Enhanced chemoresistance by elevation of p185neu levels in HER-2/neu-transfected human lung cancer cells.在HER-2/neu转染的人肺癌细胞中，通过提高p185neu水平增强化学抗性。

J Natl Cancer Inst. 1995 May 3;87(9):682-4. doi: 10.1093/jnci/87.9.682.

Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin.大黄素对HER-2/neu过表达乳腺癌细胞的转化抑制和诱导分化作用

Cancer Res. 1995 Sep 1;55(17):3890-6.

p185neu is phosphorylated on tyrosine in human primary breast tumors which overexpress neu/erbB-2.

Oncogene. 1990 Jun;5(6):879-83.

Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin.酪氨酸激酶抑制剂大黄素使HER-2/neu过表达的非小细胞肺癌细胞对化疗药物敏感

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Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, and cell proliferation characteristics in non-small cell lung cancer cell lines.

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Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel.酪氨酸激酶抑制剂大黄素可抑制无胸腺小鼠体内HER-2/neu过表达乳腺癌细胞的生长，并使这些细胞对紫杉醇的抑制作用敏感。

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c-erbB-2/neu overexpression enhances metastatic potential of human lung cancer cells by induction of metastasis-associated properties.c-erbB-2/neu过表达通过诱导转移相关特性增强人肺癌细胞的转移潜能。

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Inhibition of p185neu kinase activity and cellular transformation by co-expression of a truncated neu protein.通过共表达截短的neu蛋白抑制p185neu激酶活性和细胞转化。

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Absence of autophosphorylation site Y882 in the p185neu oncogene product correlates with a reduction of transforming potential.p185neu癌基因产物中自磷酸化位点Y882的缺失与转化潜能的降低相关。

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Inhibition of a naturally occurring EGFR oncoprotein by the p185neu ectodomain: implications for subdomain contributions to receptor assembly.p185neu胞外结构域对天然存在的表皮生长因子受体（EGFR）癌蛋白的抑制作用：亚结构域对受体组装的贡献

Oncogene. 1998 Mar 5;16(9):1197-207. doi: 10.1038/sj.onc.1201635.

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