Manin M, Delost P
J Physiol (Paris). 1978;74(8):687-93.
Continuous infusion of increasing unlabelled cortisol concentrations and tritiated cortisol was used to state precisely the relation between metabolic clearance rate of cortisol (MCR) and blood cortisol levels, on conscious male adult guinea-pigs under chronic cannulation and treated by dexamethasone. The MCR of cortisol depends on blood cortisol levels : constant for low values of cortisol concentrations (5 and 20 micrograms/100 ml), it rises 50 % between 20 and 50 micrograms/100 ml : from cortisol levels of 50 to 300 micrograms/100 ml, it reaches a maximala and constant value.
在慢性插管并接受地塞米松治疗的成年雄性豚鼠身上，持续输注不断增加的未标记皮质醇浓度和氚化皮质醇，以精确阐明皮质醇代谢清除率（MCR）与血皮质醇水平之间的关系。皮质醇的MCR取决于血皮质醇水平：皮质醇浓度较低（5和20微克/100毫升）时保持恒定，在20至50微克/100毫升之间上升50%；从皮质醇水平50至300微克/100毫升，它达到最大值并保持恒定。
