Dieterle S, Mahony J B, Luinstra K E, Stibbe W
Department of Obstetrics and Gynecology, Medical School of Hannover, Germany.
Hum Reprod. 1995 Feb;10(2):315-9. doi: 10.1093/oxfordjournals.humrep.a135934.
The role of Chlamydia (C.) trachomatis in male infertility is controversial. The objective of this study was to determine the prevalence of asymptomatic C. trachomatis infections in male partners of infertile couples, and to compare this result with the presence of chlamydial antibodies in serum and semen. C.trachomatis was detected in five of 50 semen specimens (10%) by either polymerase chain reaction for C. trachomatis DNA or direct DNA probing for C. trachomatis rRNA. There was no association between the detection of C. trachomatis in semen and the presence of chlamydial antibodies in serum or semen. Chlamydial serum antibodies were neither associated with antiserum serum antibodies nor with pathological standard semen parameters. These results indicate that the assessment of chlamydial immunoglobulin IgG and IgA antibodies in serum or semen is of limited use in male infertility work-up, in contrast to its significance in female tubal infertility. The presence of C. trachomatis in semen emphasizes the potential risk of transmission during artificial insemination and other assisted reproductive techniques, and underlines the importance of sensitive direct detection methods in this group of patients.
沙眼衣原体在男性不育症中的作用存在争议。本研究的目的是确定不育夫妇男性伴侣中无症状沙眼衣原体感染的患病率，并将该结果与血清和精液中衣原体抗体的存在情况进行比较。通过针对沙眼衣原体DNA的聚合酶链反应或针对沙眼衣原体rRNA的直接DNA探针检测，在50份精液标本中有5份（10%）检测到沙眼衣原体。精液中沙眼衣原体的检测与血清或精液中衣原体抗体的存在之间没有关联。衣原体血清抗体既不与抗血清血清抗体相关，也不与病理标准精液参数相关。这些结果表明，与衣原体免疫球蛋白IgG和IgA抗体在女性输卵管性不孕中的意义相比，血清或精液中衣原体免疫球蛋白IgG和IgA抗体的评估在男性不育症检查中的作用有限。精液中沙眼衣原体的存在强调了人工授精和其他辅助生殖技术期间传播的潜在风险，并突出了敏感直接检测方法在这类患者中的重要性。
