Andrology Centre, Tartu University Hospital, Ludvig Puusepa 8 Street, 50406 Tartu, Estonia.
Faculty of Medicine, University of Tartu, Ravila 19 Street, 50411 Tartu, Estonia.
Int J Mol Sci. 2021 Dec 15;22(24):13467. doi: 10.3390/ijms222413467.
The impact of sexually transmitted infections (STI) on male fertility is controversial. Aims: To investigate the prevalence of urethritis-associated STIs (chlamydia, gonorrhoeae, , trichomoniasis) among infertile males; to analyze the effect of STIs on semen parameters and blood PSA. Case-control study. Study group ( = 2000): males with fertility problems or desire for fertility check. Control group ( = 248): male partners of pregnant women. Analyses: polymerase chain reaction for STI, seminal interleukin 6 (IL-6), semen and fractionated urine, blood analyses (PSA, reproductive hormones). The prevalence of and chlamydia in the study group was 1.1% and 1.2%, respectively. The prevalence of chlamydia in the control group was 1.6%, while there were no cases. No cases with gonorrhoeae or trichomoniasis or combined infections were observed in neither group. There was a higher seminal concentration of neutrophils and IL-6 among positives compared with STI negatives. There was a trend toward a lower total count of spermatozoa and progressive motility among STI positives. No impact of STIs on PSA was found. The prevalence of STIs among infertile males is low. is associated with seminal inflammation. The impact of STIs on semen parameters deserves further investigations.
性传播感染（STI）对男性生育力的影响存在争议。目的：调查不育男性中尿道炎相关 STI（衣原体、淋病奈瑟菌、滴虫）的流行情况；分析 STI 对精液参数和血 PSA 的影响。病例对照研究。研究组（n=2000）：有生育问题或希望进行生育检查的男性。对照组（n=248）：孕妇的男性伴侣。分析：采用聚合酶链反应检测 STI，精液白细胞介素 6（IL-6），精液和尿分段，血液分析（PSA、生殖激素）。研究组和对照组中衣原体和衣原体的患病率分别为 1.1%和 1.2%。对照组中衣原体的患病率为 1.6%，而无淋病奈瑟菌病例。两组均未发现淋病奈瑟菌或滴虫病或混合感染。与 STI 阴性者相比，阳性者的精液中性粒细胞和 IL-6 浓度更高。STI 阳性者的总精子数和前向运动精子数呈下降趋势。未发现 STI 对 PSA 有影响。不育男性 STI 的患病率较低。衣原体与精液炎症有关。STI 对精液参数的影响值得进一步研究。
