Bishop N J, Williams D M, Compston J C, Stirling D M, Prentice A
Department of Paediatrics, Addenbrooke's Hospital, Cambridge.
Br J Haematol. 1995 Apr;89(4):927-8. doi: 10.1111/j.1365-2141.1995.tb08441.x.
Recombinant human granulocyte colony-stimulating factor (G-CSF) has substantially improved life expectancy for children with severe congenital neutropenia (SCN). Severe osteoporosis, reported in this population, may relate to the disease process, or be a therapeutic side-effect. This report details bone loss, quantitated absorptiometrically and histomorphometrically, in a child with SCN and vertebral collapse, and the positive response to anabolic steroid and bisphosphonate therapy.
重组人粒细胞集落刺激因子（G-CSF）显著提高了严重先天性中性粒细胞减少症（SCN）患儿的预期寿命。该人群中报告的严重骨质疏松症可能与疾病进程有关，或为治疗的副作用。本报告详细介绍了一名患有SCN和椎体塌陷的儿童通过骨密度测定法和组织形态计量学定量的骨质流失情况，以及对合成代谢类固醇和双膦酸盐治疗的积极反应。
