Yin Z F, Wu M C, Yu Z Q
Changhai Hospital, Second Military Medical University.
Zhonghua Wai Ke Za Zhi. 1994 Nov;32(11):654-6.
Postoperative change of focusylation index (FI) of serum alpha-fetoprotein (F-AFP) and the result of surgery were studied in 34 patients of hepatocellular carcinoma. In 23 patients, serum F-AFP was disappeared with serum AFP turning negative and no tumor recurrence heppaned within the first 6 months postoperatively. In 4 patients, owing to hepatitis or active cirrohosis in the remained liver, serum AFP didn't turn negative, but FI of AFP was obviously decreased, follow-up found no signs of tumor recurrence within the first 6 months. In 5 of 7 patients, with decreased postoperative serum AFP levels and unchanged FI, tumor recurred. These results showed that postoperative F-AFP monitoring is helpful in evaluating surgical efficacy in liver tumor producing AFP.
对34例肝细胞癌患者研究了血清甲胎蛋白聚焦化指数（FI）的术后变化以及手术结果。23例患者血清F-AFP消失，血清AFP转为阴性，术后前6个月内未发生肿瘤复发。4例患者，由于剩余肝脏存在肝炎或活动性肝硬化，血清AFP未转为阴性，但AFP的FI明显降低，随访发现前6个月内无肿瘤复发迹象。7例患者中有5例，术后血清AFP水平降低但FI未变，肿瘤复发。这些结果表明，术后F-AFP监测有助于评估产生AFP的肝肿瘤的手术疗效。
