Gurevitch J, Paz Y, Barak J, Matsa M, Kramer A, Pevni D, Hochhauser E, Yakirevich V
Department of Thoracic and Cardiovascular Surgery, Elias Souraski, Tel-Aviv Medical Center, Tel-Aviv University, Israel.
J Cardiovasc Surg (Torino). 1994 Dec;35(6 Suppl 1):95-8.
Aprotinin, a naturally occurring protease inhibitor, in concentrations of 10(6) KIU/L was found to have no effect on myocardial performance in normally perfused isolated rat hearts, before ischemia. Given during the preischemic period, the drug had a significant protective effect on the reperfused hearts, following cardioplegic ischemia: better contractility upon reperfusion (p < 0.011), faster decline of the ischemic contracture, higher coronary flow (p < 0.025), lower AV-difference (p < 0.05), and lower CPK levels (p < 0.01).
抑肽酶是一种天然存在的蛋白酶抑制剂，发现在正常灌注的离体大鼠心脏缺血前，浓度为10(6) KIU/L时对心肌性能无影响。在缺血前期给予该药物，对停搏缺血后的再灌注心脏有显著保护作用：再灌注时收缩性更好（p < 0.011），缺血性挛缩下降更快，冠状动脉血流量更高（p < 0.025），房室压差更低（p < 0.05），肌酸磷酸激酶水平更低（p < 0.01）。
