Kajander K C, Xu J
Department of Oral Science, University of Minnesota, Minneapolis 55455-0329, USA.
Neurosci Lett. 1995 Feb 17;186(2-3):184-8. doi: 10.1016/0304-3940(95)11294-7.
Levels of calcitonin gene-related peptide immunoreactivity (CGRP-ir) and substance P immunoreactivity (SP-ir) in the lumbar dorsal spinal cord of rats with either sciatic nerve transection or chronic constriction injury (CCI) were measured using radioimmunoassay. Significant decreases in CGRP-ir and SP-ir occurred in the ipsilateral spinal cord at 10 and 31 days after nerve transection. An ipsilateral decrease in SP-ir occurred 60 days after CCI. In addition, contralateral decreases in CGRP-ir and SP-ir occurred 31 days after transection and 60 days after CCI. Transection of the sciatic nerve produced greater decreases in peptide levels than did the CCI. Changes in spinal levels of these peptides may be involved in the appearance of neuropathic signs associated with nerve injury.
采用放射免疫分析法测定坐骨神经横断或慢性压迫损伤（CCI）大鼠腰段背侧脊髓中降钙素基因相关肽免疫反应性（CGRP-ir）和P物质免疫反应性（SP-ir）的水平。神经横断后10天和31天，同侧脊髓中CGRP-ir和SP-ir显著降低。CCI后60天，同侧SP-ir降低。此外，横断后31天和CCI后60天，对侧CGRP-ir和SP-ir降低。坐骨神经横断比CCI导致肽水平下降更明显。这些肽在脊髓水平的变化可能与神经损伤相关的神经病理性体征的出现有关。
