Lindner J, Skokanová V
II. chirurgická klinika, 1. LF UK Praha.
Rozhl Chir. 1995 Feb;74(1):21-4.
The submitted investigation deals with the value of assessment of selected reactants of the acute stage in patients with acute pancreatitis and their follow-up in the course of the disease. For the investigation C-reactive protein, alpha-1-antitrypsin and haptaglobin were selected. In addition to the prognostic impact the authors focused attention on assessment of the dynamics of individual proteins and their importance for the early detection of complications in acute pancreatitis with different etiologies. The high CRP level on admission of severe cases of pancreatitis--mean 166.9 mg/l (range from 100 to 320 mg/l)--correlated with other signs suggesting severe pancreatitis and the latter was confirmed by computed tomography (CT), surgery or post-mortem examination in 90% of the patients with a CRP level above 100 mg/l. This correlation was not confirmed for alpha-1-antitrypsin or haptaglobin.
本提交的研究涉及急性胰腺炎患者急性期特定反应物评估的价值及其在疾病过程中的随访情况。研究选取了C反应蛋白、α-1抗胰蛋白酶和触珠蛋白。除了预后影响外，作者还关注个体蛋白质动态变化的评估及其对不同病因急性胰腺炎并发症早期检测的重要性。重症胰腺炎患者入院时的高C反应蛋白水平——平均为166.9毫克/升（范围为100至320毫克/升）——与提示重症胰腺炎的其他体征相关，在C反应蛋白水平高于100毫克/升的患者中，90%通过计算机断层扫描（CT）、手术或尸检得到证实。α-1抗胰蛋白酶或触珠蛋白未证实存在这种相关性。
