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The CFTR chloride channel of mammalian heart.

作者信息

Gadsby D C, Nagel G, Hwang T C

机构信息

Laboratory of Cardiac and Membrane Physiology, Rockefeller University, New York, NY 10021, USA.

出版信息

Annu Rev Physiol. 1995;57:387-416. doi: 10.1146/annurev.ph.57.030195.002131.

DOI:10.1146/annurev.ph.57.030195.002131
PMID:7539989
Abstract
摘要

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The CFTR chloride channel of mammalian heart.哺乳动物心脏的囊性纤维化跨膜传导调节因子氯离子通道。
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The cystic fibrosis mutation (delta F508) does not influence the chloride channel activity of CFTR.囊性纤维化突变(ΔF508)不影响囊性纤维化跨膜传导调节因子的氯离子通道活性。
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The amino-terminal portion of CFTR forms a regulated Cl- channel.囊性纤维化跨膜传导调节因子(CFTR)的氨基末端部分形成一个受调控的氯离子通道。
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CFTR Cl- channel and CFTR-associated ATP channel: distinct pores regulated by common gates.囊性纤维化跨膜传导调节因子氯离子通道及与囊性纤维化跨膜传导调节因子相关的ATP通道:由共同闸门调控的不同孔道
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The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating.囊性纤维化跨膜传导调节因子苯丙氨酸508侧链在离子通道门控中的作用。
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Conformational states of CFTR associated with channel gating: the role ATP binding and hydrolysis.与通道门控相关的囊性纤维化跨膜传导调节因子(CFTR)的构象状态:ATP结合与水解的作用
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Walker mutations reveal loose relationship between catalytic and channel-gating activities of purified CFTR (cystic fibrosis transmembrane conductance regulator).沃克突变揭示了纯化的囊性纤维化跨膜传导调节因子(CFTR)的催化活性与通道门控活性之间的松散关系。
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The protein kinase A-regulated cardiac Cl- channel resembles the cystic fibrosis transmembrane conductance regulator.蛋白激酶A调节的心脏氯离子通道类似于囊性纤维化跨膜传导调节因子。
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ClC and CFTR chloride channel gating.氯离子通道(ClC)和囊性纤维化跨膜传导调节因子(CFTR)氯离子通道门控
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