Sameshima K
Department of Orthopaedic Surgery, Kagoshima University, Faculty of Medicine, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1995 Apr;69(4):191-7.
Substance P-like immunoreactivity (SP-LI) of the cerebrospinal fluid was measured by radioimmunoassay in 40 patients with lumbar disc herniation (hernia group), and in 10 patients with no low back pain and no leg symptoms (control group). The SP-LI was significantly higher in the hernia group (5.49 +/- 3.01 pg/ml) than in the control group (2.05 +/- 0.52 pg/ml) (p < 0.01). In the hernia group, the SP-LI was significantly higher in patients with severe pain in the lower extremities than in those with only mild pain. As the SP-LI was found to be correlated with the severity of pain, it was considered to be a useful index of pain. As for the correlation of SP-LI with the hernia type, the SP-LI was significantly higher in patients with transligamentous extrusion type hernia than in those with protrusion type hernia. This result suggested that the release of substance P was increased with marked compression on the dorsal root.
采用放射免疫分析法测定了40例腰椎间盘突出症患者（疝组）和10例无腰痛及腿部症状患者（对照组）脑脊液中P物质样免疫反应性（SP-LI）。疝组的SP-LI（5.49±3.01 pg/ml）显著高于对照组（2.05±0.52 pg/ml）（p<0.01）。在疝组中，下肢剧痛患者的SP-LI显著高于仅有轻度疼痛的患者。由于发现SP-LI与疼痛严重程度相关，故认为它是疼痛的一个有用指标。至于SP-LI与疝类型的相关性，韧带下突出型疝患者的SP-LI显著高于突出型疝患者。该结果提示，随着背根受到明显压迫，P物质的释放增加。
