Kura Y, Sawada U, Tsuboi I, Suzuki K, Yamazaki T, Satou Y, Horie T
First Department of Internal Medicine, Nihon University School of Medicine, Tokyo.
Rinsho Ketsueki. 1995 Mar;36(3):227-9.
A case of NHL which has been in long-term remission following vigorous treatment for CNS relapse with intrathecal administration of Ara-C and focal irradiation to the brain is presented. The patient was a 61-year-old man, who was successfully treated with CHOP followed by MACOP-B for diffuse large cell NHL in 1988. Five months later he was admitted to our hospital because of loss of visual acquity and numbness in the right upper and lower extremities. The presence of lymphoma cells in CSF, abnormal shadow in the left frontal lobe on a cranial CT scan and MRI scan, and positive Ga scintigraphy yielded a diagnosis of CNS relapse of NHL. Twenty one whole brain and additional 1.0Gy to the left frontal lobe of irradiation were performed. Eight days later the left tumor disappeared. Neurological remission was obtained and has continued until now.
本文报告1例非霍奇金淋巴瘤（NHL）患者，经鞘内注射阿糖胞苷（Ara-C）及脑部局部放疗积极治疗中枢神经系统复发后长期缓解。患者为61岁男性，1988年因弥漫性大细胞NHL成功接受CHOP方案治疗，随后接受MACOP-B方案治疗。5个月后，因视力丧失及右上肢和下肢麻木入院。脑脊液中存在淋巴瘤细胞、头颅CT扫描和MRI扫描显示左额叶异常阴影、镓闪烁显像阳性，确诊为NHL中枢神经系统复发。进行了21次全脑放疗，并对左额叶追加1.0Gy照射。8天后，左侧肿瘤消失。获得了神经学缓解，且一直持续至今。
