3'-叠氮-3'-脱氧胸苷（AZT）和戈西利克亚胺内酯（GIL）对HIV-1临床分离株的抗病毒活性比较。
Comparison of the antiviral activities of 3'-azido-3'-deoxythymidine (AZT) and gossylic iminolactone (GIL) against clinical isolates of HIV-1.
作者信息
Royer R E, Mills R G, Young S A, Vander Jagt D L
机构信息
Department of Biochemistry, University of New Mexico School of Medicine, Albuquerque 87131, USA.
出版信息
Pharmacol Res. 1995 Jan;31(1):49-52. doi: 10.1016/1043-6618(95)80047-6.
3'-Azido-3'-deoxythymidine (AZT) and gossylic iminolactone (GIL) were compared for antiviral activities in vitro against fresh clinical isolates of HIV-1 obtained from 19 subjects on AZT therapy. IC50 values for AZT ranged from 0.015 to 6.7 microM (447-fold range) while IC50 values for GIL ranged from 0.40 to 6.6 microM (16-fold range). There was no correlation between IC50 values for AZT and GIL, suggesting that the anti-HIV activity of GIL does not involve inhibition of reverse transcriptase.
对3'-叠氮-3'-脱氧胸苷（AZT）和戈氏亚胺内酯（GIL）进行了体外抗病毒活性比较，以对抗从19名接受AZT治疗的受试者中获得的HIV-1新鲜临床分离株。AZT的IC50值范围为0.015至6.7微摩尔（447倍范围），而GIL的IC50值范围为0.40至6.6微摩尔（16倍范围）。AZT和GIL的IC50值之间没有相关性，这表明GIL的抗HIV活性不涉及对逆转录酶的抑制。
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