Neĭmark A I, Malazoniia Z T, Karabasova E B
Urol Nefrol (Mosk). 1995 Mar-Apr(2):27-9.
61 patients suffering from chronic pyelonephritis in the stage of active inflammation associated with either urolithiasis (67.4%) or prostatic adenoma (32.6%) were divided into three groups. Group 1 received conventional antibacterial treatment, group 2 conventional treatment + local laser radiation (LLR), group 3 received combined therapy including intravascular laser irradiation of blood (IVLIB). The treatments efficacy was controlled by urine seeding for microflora and its sensitivity to antibiotics, by immunological supervision. The patients were found to have immunological abnormalities in the form of cellular and humoral immunity suppression, neutrophil phagocytic hypoactivity, elevated levels of medium-molecular peptides nonresponsive to standard antibacterial therapy. Adjuvant use of LLR improved humoral immunity and reduced total urine bacterial count. LLR replacement for IVLIB resulted in a complete regression of immunological shifts and more pronounced reduction of urinary bacterial contamination.
61例患有慢性肾盂肾炎且处于活动炎症期的患者，伴有尿路结石（67.4%）或前列腺腺瘤（32.6%），被分为三组。第1组接受常规抗菌治疗，第2组接受常规治疗+局部激光照射（LLR），第3组接受包括血液血管内激光照射（IVLIB）的联合治疗。通过对尿液中微生物群落及其对抗生素的敏感性进行尿液接种，并通过免疫监测来控制治疗效果。发现患者存在免疫异常，表现为细胞免疫和体液免疫抑制、中性粒细胞吞噬活性低下、对标准抗菌治疗无反应的中分子肽水平升高。辅助使用LLR可改善体液免疫并降低尿液细菌总数。用LLR替代IVLIB导致免疫变化完全消退，并更显著地降低尿液细菌污染。
