David M
Division of Cytokine Biology, Center of Biologics Evaluation and Research, Bethesda MD 20892, USA.
Pharmacol Ther. 1995 Feb;65(2):149-61. doi: 10.1016/0163-7258(94)00050-d.
Interferons (IFNs) comprise a family of polypeptides that exhibit diverse biological effects such as inhibition of cell growth and protection against viral infection. These activities are based mainly on the transcriptional induction of cellular genes by both type I (IFN-alpha and IFN-beta) and type II (IFN-gamma) interferons. Several of these IFN-induced early response genes have been cloned and common elements within their promoters defined. Transcription factors, such as interferon-stimulated gene factor-3, IFN-gamma activation factor and FcRF gamma, that bind to these enhancers subsequently have been isolated and their components identified. This review shall provide an overview of the DNA response elements, the components of the IFN-induced transcription factors and their mechanism of action.
干扰素（IFNs）是一类多肽家族，具有多种生物学效应，如抑制细胞生长和抵御病毒感染。这些活性主要基于I型（IFN-α和IFN-β）和II型（IFN-γ）干扰素对细胞基因的转录诱导。其中一些IFN诱导的早期反应基因已被克隆，并确定了其启动子中的共同元件。随后分离出了与这些增强子结合的转录因子，如干扰素刺激基因因子-3、IFN-γ激活因子和FcRFγ，并确定了它们的组成成分。本综述将概述DNA反应元件、IFN诱导的转录因子的组成成分及其作用机制。
