Athanasas-Platsis S, Savage N W, Winning T A, Walsh L J
Department of Dentistry, University of Queensland, Brisbane, Australia.
Arch Oral Biol. 1995 Feb;40(2):157-60. doi: 10.1016/0003-9969(94)00152-2.
Monocytes have recently been recognized as a precursor of Langerhans cells. This study examined the regulatory influence of the epithelial environment on the putative first step of the transition towards a Langerhans cell phenotype--the induction of CD1a antigen. The keratinocyte-derived cytokines granulocyte-macrophage-colony-stimulating factor, tumour necrosis factor-alpha, interleukin-6, and interleukin-1 beta induced CD1a expression, as did supernatants of keratinocytes extracted from inflammatory sites (periodontitis). Induction was abrogated by transforming growth factor-beta and a keratinocyte-derived interleukin-1 inhibitor. The optimal temperature for induction was 34 degrees C, not 37 degrees C. These results demonstrate that the components of the epithelial environment (cytokines and lower temperature) exert important influences, which may be part of local regulation of Langerhans cell development.
单核细胞最近被认为是朗格汉斯细胞的前体。本研究检测了上皮环境对向朗格汉斯细胞表型转变的假定第一步——CD1a抗原诱导的调节影响。角质形成细胞衍生的细胞因子粒细胞-巨噬细胞集落刺激因子、肿瘤坏死因子-α、白细胞介素-6和白细胞介素-1β可诱导CD1a表达，从炎症部位（牙周炎）提取的角质形成细胞的上清液也可诱导CD1a表达。转化生长因子-β和角质形成细胞衍生的白细胞介素-1抑制剂可消除诱导作用。诱导的最佳温度为34℃，而非37℃。这些结果表明，上皮环境的成分（细胞因子和较低温度）发挥着重要影响，这可能是朗格汉斯细胞发育局部调节的一部分。
