Maeda Sachiko, Kai Keita, Kawasaki Kanako, Tanaka Tomokazu, Ide Takao, Noshiro Hirokazu
Department of Pathology & Microbiology, Faculty of Medicine, Saga University, Saga 849-8501, Japan.
Department of Surgery, Faculty of Medicine, Saga University, Saga 849-8501, Japan.
Int J Mol Sci. 2024 Nov 27;25(23):12763. doi: 10.3390/ijms252312763.
Dendritic cells (DCs) are known to be major antigen-presenting cells, and lymph nodes (LNs) play an important role in DC-mediated immune response. CD1a is known as a marker of monocyte-derived DCs. The present study focused on the infiltration of CD1a-positive DCs (CD1a-DCs) into regional LNs in 70 cases of gallbladder cancer (GBC). After univariate analyses, the results showed that LN infiltration by CD1a-DCs was associated with unfavorable clinical outcomes in patients with GBC, with all cases categorized in the CD1a-DCs high group had nodal metastasis. LN infiltration by CD1a-DCs was not an independent prognostic factor identified by multivariate analyses. After subgroup analyses of cases with LN metastasis ( = 32), no significant impacts of CD1a-DCs infiltration into metastatic LNs were observed. In contrast, CD1a-DCs infiltration into primary tumors had a significant impact on surgical outcomes. The results of strong confounding between CD1a-DCs and LN metastasis support the theory that CD1a-DCs are developed from monocytes at tumor sites. As the results of previous research focused on CD1a-DCs infiltration into regional LNs of other organs varied, the role and significance of CD1a-DCs infiltration in regional LNs may be different according to the tumor histology or its primary site. Thus, further studies are needed to clarify the role and significance of CD1a-DCs infiltration into regional LNs of solid cancers.
树突状细胞（DCs）是主要的抗原呈递细胞，淋巴结（LNs）在DC介导的免疫反应中起重要作用。CD1a是单核细胞衍生DCs的标志物。本研究聚焦于70例胆囊癌（GBC）患者区域淋巴结中CD1a阳性DCs（CD1a-DCs）的浸润情况。单因素分析结果显示，CD1a-DCs浸润淋巴结与GBC患者不良临床结局相关，所有归入CD1a-DCs高组的病例均有淋巴结转移。多因素分析未将CD1a-DCs浸润淋巴结确定为独立预后因素。对有淋巴结转移的病例（n = 32）进行亚组分析后，未观察到CD1a-DCs浸润转移淋巴结有显著影响。相反，CD1a-DCs浸润原发性肿瘤对手术结局有显著影响。CD1a-DCs与淋巴结转移之间存在强烈混杂的结果支持了CD1a-DCs是在肿瘤部位由单核细胞发育而来的理论。由于先前针对CD1a-DCs浸润其他器官区域淋巴结的研究结果各异，CD1a-DCs浸润区域淋巴结的作用和意义可能因肿瘤组织学类型或原发部位而异。因此，需要进一步研究以阐明CD1a-DCs浸润实体癌区域淋巴结的作用和意义。
