Ang L C, Shul D D
Department of Pathology, University of Toronto, Sunnybrook Health Science Centre, North York, Ont., Canada.
Brain Res. 1995 Mar 20;674(2):329-35. doi: 10.1016/0006-8993(95)00034-n.
Most of the neurons in the subcortical white matter of the adult cerebrum are remnants of the transient subplate cortex which appears during early cortical development. The peptidergic neurons in the subcortical white matter, beneath the striate cortex were examined qualitatively and qualitatively with immunohistochemistry for substance P, cholecystokinin, somatostatin and neuropeptide Y in seven control patients and eight patients with Alzheimer's disease. The different peptidergic subcortical neurons still persisted in normal aging. In Alzheimer's disease, however, the substance P- and somatostatin-immunoreactive neurons were decreased in numbers and showed degenerative changes.
成年大脑皮质下白质中的大多数神经元是早期皮质发育过程中出现的短暂性皮质下板层皮质的残余物。对7名对照患者和8名阿尔茨海默病患者，采用免疫组织化学方法对纹状皮质下方皮质下白质中的肽能神经元进行了P物质、胆囊收缩素、生长抑素和神经肽Y的定性和定量检测。不同的肽能皮质下神经元在正常衰老过程中仍然存在。然而，在阿尔茨海默病中，P物质和生长抑素免疫反应性神经元数量减少，并出现退行性变化。
