Plata C, Algaba F, Andújar M, Nistal M, Stocks P, Martínez J L, Nogales F F
Department of Pathology, University Hospital, Granada, Spain.
Histopathology. 1995 Mar;26(3):255-9. doi: 10.1111/j.1365-2559.1995.tb01439.x.
Five cases of large cell calcifying Sertoli cell tumour of the testis not associated with complex dysplastic syndromes are reported. The age of the patients ranged from 13 to 34 years and all the tumours were histologically similar, having large, isomorphic, non-mitotic, eosinophilic Sertoli cells with foci of calcification. Flow cytometry demonstrated the cells to be diploid or hypodiploid. All cases were positive for vimentin and focally positive for low molecular weight keratin. The present cases, together with a review of the 22 previously reported tumours, demonstrate that there are two clear cut types of large cell calcifying Sertoli cell tumour; those which are associated with complex dysplastic syndromes and which are bilateral and multifocal, and those which are not associated and are unilateral and focal. Prognosis in all of our cases was uniformly good despite invasion of the rete testis in two cases. It is considered that conservative resection of the tumour is the treatment of choice in cases not associated with complex dysplastic syndromes, since the malignancy rate is low.
报告了5例睾丸大细胞钙化性支持细胞瘤，这些病例均与复杂发育异常综合征无关。患者年龄在13至34岁之间，所有肿瘤在组织学上均相似，具有大的、同形的、无有丝分裂的嗜酸性支持细胞，并伴有钙化灶。流式细胞术显示细胞为二倍体或亚二倍体。所有病例波形蛋白均呈阳性，低分子量角蛋白呈局灶性阳性。本病例以及对先前报道的22例肿瘤的回顾表明，大细胞钙化性支持细胞瘤有两种明确的类型：与复杂发育异常综合征相关的双侧多灶性肿瘤，以及与之无关的单侧局灶性肿瘤。尽管有2例肿瘤侵犯了睾丸网，但我们所有病例的预后均良好。对于与复杂发育异常综合征无关的病例，考虑到恶性率较低，认为肿瘤的保守切除是首选治疗方法。
