罕见睾丸癌组织学类型的治疗策略：伴有恶性转化的畸胎瘤和恶性睾丸性索间质肿瘤。
Therapeutic strategies for uncommon testis cancer histologies: teratoma with malignant transformation and malignant testicular sex cord stromal tumors.
作者信息
Azizi Mounsif, Aydin Ahmet M, Cheriyan Salim K, Peyton Charles C, Montanarella Matthew, Gilbert Scott M, Sexton Wade J
机构信息
Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
出版信息
Transl Androl Urol. 2020 Jan;9(Suppl 1):S91-S103. doi: 10.21037/tau.2019.09.08.
Abstract
Testicular cancer is the most common solid malignancy in male adolescents and young adults, with germ cell derived seminomas and non-seminomas being by far the most common histologies. Teratoma with somatic-type malignancy is a rare chemo-resistant phenotype of testis cancer associated with poor prognosis in patients with advanced stage disease. Malignant gonadal-stromal tumors comprise 5% of testicular neoplasms and approximately 10% are malignant and considered chemo-radiation resistant. Prognostic factors and treatment strategies for these uncommon histologies are lacking.
摘要
睾丸癌是男性青少年和青年中最常见的实体恶性肿瘤，其中生殖细胞来源的精原细胞瘤和非精原细胞瘤是迄今为止最常见的组织学类型。伴有体细胞型恶性肿瘤的畸胎瘤是睾丸癌一种罕见的化疗耐药表型，与晚期疾病患者的不良预后相关。恶性性腺间质肿瘤占睾丸肿瘤的5%，约10%为恶性且被认为对放化疗耐药。目前缺乏针对这些不常见组织学类型的预后因素和治疗策略。
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