Retrograde axonal cytokine transport: a pathway for immunostimulation in the brain inducing hypoxia and sudden infant death?

The etiology and pathogenesis of sudden infant death syndrome (SIDS) remain unknown. A hypothesis for SIDS should explain three characteristic findings: (a) an age distribution peaking at 2-4 months; (b) frequent association with respiratory tract infections; and (c) occurrence during sleep. The diagnosis of SIDS is applied when death cannot be explained, and this syndrome therefore probably includes various underlying causes. Based on recent observations, however, we suggest a pathogenic pathway that might be common to most SIDS victims.