Schwyzer R
Department of Molecular Biology and Biophysics, Swiss Federal Institute of Technology, Zürich.
J Mol Recognit. 1995 Jan-Apr;8(1-2):3-8. doi: 10.1002/jmr.300080103.
Conformations of regulatory peptides interacting with artificial lipid membranes were compared with those of chemically constrained molecules that react selectively with different receptor classes. Striking similarities in the topochemistry of molecules with similar activity were observed. The membrane-induced topomers were almost congruent with the artificial topomers that are selectively recognized by the same receptors. Finally, the ideas developed in the membrane compartments theory which allow a quantitative prediction of receptor preference are compatible with our present knowledge of receptor structure.
将与人工脂质膜相互作用的调节肽的构象与那些与不同受体类别选择性反应的化学约束分子的构象进行了比较。观察到具有相似活性的分子在拓扑化学上有显著相似性。膜诱导的拓扑异构体几乎与被相同受体选择性识别的人工拓扑异构体一致。最后，膜区室理论中发展出的能够对受体偏好进行定量预测的观点与我们目前对受体结构的认识是相符的。
