Christodoulou C N, Zonas C, Loukaides T, Maniatis A, Giannikos L, Giannakopoulos C, Fassoula M
Laiko General Hospital, Athens, Greece.
Ultrasound Obstet Gynecol. 1995 Apr;5(4):267-70. doi: 10.1046/j.1469-0705.1995.05040267.x.
Seven pregnancies with positive fetal heart activity and low or very low serum beta-human chorionic gonadotropin (beta-hCG) levels were investigated. The gestational age by dates was between 6 weeks 3 days and 8 weeks 4 days at the time of the first ultrasound scan and beta-hCG ranged between 282 and 10,000 mIU/ml of the Second International Standard. The crown-rump lengths ranged between 6 and 13 mm and heart activity was always detected. Four cases were scanned because beta-hCG was lower than that expected for the gestational age; in these cases the yolk sac was present but the gestational sacs were small, with a trophoblastic ring that looked thin and subjectively seemed abnormal. The beta-hCG level was measured in the other three cases, because the gestational sacs were small and had a thin trophoblastic ring. In these cases, fetal heart activity was clearly imaged. All cases were scheduled for a repeat ultrasound scan 2 weeks later. Three cases aborted spontaneously the following week, whereas in the other four no heart activity was detected in a repeat sonogram 2 weeks later. Low serum beta-hCG levels indicate a poor prognosis even when associated with an embryo with positive cardiac activity detected ultrasonographically.
对7例胎儿心脏活动阳性但血清β-人绒毛膜促性腺激素（β-hCG）水平低或极低的妊娠情况进行了研究。首次超声扫描时，根据末次月经计算的孕周在6周3天至8周4天之间，β-hCG水平在第二国际标准的282至10,000 mIU/ml之间。头臀长度在6至13毫米之间，且均检测到心脏活动。4例因β-hCG低于孕周预期值而进行扫描；在这些病例中，存在卵黄囊，但妊娠囊较小，滋养层环看起来较薄且主观上似乎异常。另外3例因妊娠囊小且滋养层环薄而测量了β-hCG水平。在这些病例中，胎儿心脏活动清晰成像。所有病例均安排在2周后进行重复超声扫描。其中3例在接下来的一周自然流产，而另外4例在2周后的重复超声检查中未检测到心脏活动。血清β-hCG水平低表明预后不良，即使与超声检查发现的有心脏活动的胚胎相关。
