Chen G, Qian L, Shen D
Institute of Hematology, CAMS, Tianjin.
Zhonghua Nei Ke Za Zhi. 1995 Jan;34(1):26-9.
Antigen CD34 and other markers of cell membrane were investigated in cells from 43 patients with primary acute nonlymphoblastic leukemia (ANLL) by immunofluorescence test. The blast cells of 13 patients (30.2%) expressed antigen CD34. The patients with positive CD34 were no significantly different from the remaining 30 patients with negative CD34 with respect to age, serum lactate dehydrogenase (LDH), hemoglobin, white blood cell count, platelet count and the proportion of blast cells in blood and bone marrow, but their blasts were more likely to express HLA-DR, CD38, CD7 and lack of CD15 antigen. These patients had FAB M1 or M5a morphologic characteristics and lower complete remission (CR) rate. This result demonstrated that CD34 positive ANLL is poorly differentiated.
采用免疫荧光试验对43例原发性急性非淋巴细胞白血病（ANLL）患者的细胞进行了细胞膜抗原CD34及其他标志物检测。13例患者（30.2%）的原始细胞表达抗原CD34。CD34阳性患者与其余30例CD34阴性患者在年龄、血清乳酸脱氢酶（LDH）、血红蛋白、白细胞计数、血小板计数以及血液和骨髓中原始细胞比例方面无显著差异，但他们的原始细胞更易表达HLA-DR、CD38、CD7且缺乏CD15抗原。这些患者具有FAB M1或M5a形态学特征且完全缓解（CR）率较低。这一结果表明CD34阳性ANLL分化较差。
