Bell S A, Du Clos T W, Khursigara G, Picazo J J, Rubin R L
W.M. Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037, USA.
J Autoimmun. 1995 Apr;8(2):293-303. doi: 10.1006/jaut.1995.0022.
Toxic oil syndrome (TOS) was caused by the consumption of rapeseed oil contaminated with derivatives of aniline. Many persons who survived the acute phase developed a puzzling, multi-year chronic disease considered to be inflammatory or autoimmune in nature. In attempting to characterize their autoantibodies, we found that 74% of TOS patients with chronic disease had IgG antibodies to C-reactive protein (CRP). This activity was detectable only when CRP was chemically or physically denatured and behaved like a previously described antibody produced by immunization with the CRP monomer. Significant antibody reactivities to other acute phase proteins, especially alpha 1-antitrypsin and fibrinogen (P < 0.025) and ceruloplasmin (P < 0.05) were also observed. IgG antibodies to cryptic epitopes in CRP and other major serum proteins that increase during the acute phase response may reflect an earlier toxin-mediated insult to the liver that included abnormal biosynthesis of and/or damage to acute phase proteins.
中毒性油综合征（TOS）是由食用被苯胺衍生物污染的菜籽油引起的。许多在急性期存活下来的人患上了一种令人费解的、持续多年的慢性病，这种病被认为本质上是炎症性或自身免疫性的。在试图对他们的自身抗体进行特征描述时，我们发现74%患有慢性病的TOS患者具有抗C反应蛋白（CRP）的IgG抗体。只有当CRP在化学或物理上变性时，这种活性才能被检测到，并且其表现类似于先前描述的用CRP单体免疫产生的抗体。还观察到对其他急性期蛋白有显著的抗体反应性，特别是α1-抗胰蛋白酶和纤维蛋白原（P < 0.025）以及铜蓝蛋白（P < 0.05）。针对急性期反应期间增加的CRP和其他主要血清蛋白中隐蔽表位的IgG抗体，可能反映了早期毒素介导的对肝脏的损害，其中包括急性期蛋白的生物合成异常和/或损伤。
