PFAPA综合征患儿中抗单体C反应蛋白（CRP）自身抗体的高流行率。
High Prevalence of Autoantibodies Against Monomeric C Reactive Protein (CRP) in Children with PFAPA Syndrome.
作者信息
Kraszewska-Głomba Barbara, Myszka Marta, Krajewska Magdalena, Szenborn Leszek
机构信息
Department and Clinic of Paediatric Infectious Diseases, Wrocław Medical University, Wrocław, Poland.
Department and Clinic of Nephrology and Transplantation Medicine, Faculty of Postgraduate Medical Training, Wroclaw Medical University, Wrocław, Poland.
出版信息
J Med Biochem. 2018 Dec 1;37(4):507-509. doi: 10.1515/jomb-2017-0066. eCollection 2018 Dec.
Abstract
PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly contribute to systemic inflammation during PFAPA flares. We carried out anti-mCRP testing (in-house ELISA) in a single-center, prospective cohort of 30 PFAPA patients (12 girls). We found a high prevalence (43.3%) of anti-mCRP antibodies in PFAPA patients during their febrile episodes, which implies the possible involvement of anti-mCRP antibodies in PFAPA pathogenesis.
摘要
PFAPA（周期性发热、阿弗他口炎、咽炎、颈淋巴结炎）综合征是一种病因不明的自身炎症性疾病。我们研究的目的是评估抗修饰C反应蛋白自身抗体（anti-mCRP）的存在是否可能在PFAPA发作期间导致全身炎症。我们在一个单中心前瞻性队列中对30例PFAPA患者（12名女孩）进行了抗mCRP检测（内部酶联免疫吸附测定）。我们发现PFAPA患者在发热期抗mCRP抗体的患病率很高（43.3%），这意味着抗mCRP抗体可能参与了PFAPA的发病机制。
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