粒细胞集落刺激因子成功治疗耐沙利度胺的HIV相关口疮

Thalidomide-resistant HIV-associated aphthae successfully treated with granulocyte colony-stimulating factor.

作者信息

Manders S M, Kostman J R, Mendez L, Russin V L

机构信息

Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, USA.

出版信息

J Am Acad Dermatol. 1995 Aug;33(2 Pt 2):380-2. doi: 10.1016/0190-9622(95)91439-0.

DOI:10.1016/0190-9622(95)91439-0

PMID:7542291

Abstract

Thalidomide has been advocated as the treatment of choice for recalcitrant aphthae. We describe the case of patient with HIV infection and extensive aphthae whose condition failed to respond to corticosteroids, cyclosporine, and thalidomide. The patient's course was complicated by colonic aphthae. Rapid and sustained resolution was achieved through treatment with granulocyte colony-stimulating factor, a previously unreported therapeutic option.

摘要

沙利度胺已被推荐为难治性口疮的首选治疗药物。我们描述了一例感染人类免疫缺陷病毒（HIV）且患有广泛性口疮的患者，其病情对皮质类固醇、环孢素和沙利度胺均无反应。该患者的病程因结肠口疮而复杂化。通过使用粒细胞集落刺激因子治疗，病情迅速且持续缓解，这是一种此前未报道过的治疗选择。