用粒细胞集落刺激因子治疗人类免疫缺陷病毒感染中的中性粒细胞减少性口腔溃疡

Treatment of neutropenic oral ulceration in human immunodeficiency virus infection with G-CSF.

作者信息

Luzzi G A, Jones B J

机构信息

South Buckinghamshire NHS Trust, Wycombe General Hospital, High Wycombe, U.K.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Jan;81(1):53-4. doi: 10.1016/s1079-2104(96)80148-x.

DOI:10.1016/s1079-2104(96)80148-x

PMID:8850484

Abstract

We report the novel use of granulocyte colony-stimulating factor in the treatment of severe oral ulceration in human immunodeficiency virus-associated neutropenia. A 38-year-old man with acquired immunodeficiency syndrome developed severe refractory oral aphthous ulceration that persisted for 6 months despite a range of empirical treatments including corticosteroid. Rapid resolution of the ulceration occurred once the neutrophil count was restored to normal with granulocyte colony-stimulating factor.

摘要

我们报告了粒细胞集落刺激因子在治疗人类免疫缺陷病毒相关性中性粒细胞减少症所致严重口腔溃疡中的新用途。一名38岁的获得性免疫缺陷综合征男性患者出现严重难治性口腔阿弗他溃疡，尽管接受了包括皮质类固醇在内的一系列经验性治疗，但仍持续了6个月。使用粒细胞集落刺激因子使中性粒细胞计数恢复正常后，溃疡迅速愈合。