Serratrice G, Pellissier J F, Cros D
Rev Rhum Mal Osteoartic. 1978 Nov;45(11):621-30.
Osteomalacic myopathies are rare. They can prevail, however, and occur before bone abnormalities. The diagnosis must rest on clinical observation since the histopathologic images are not specific. On the other hand the demonstration of muscular weakness is very frequent during osteomalacia. In fact two types of manifestations correspond to the same anatomopathologic lesions. These are myopathic changes observed also during light microscopy, histoenzymologic and ultrastructural examination in the 10 patients examined. On the basis of these morphologic changes, muscular involvement can be considered to be part of the osteomalacia syndrome. The contribution of various factors including secondary hyperparathyroidism, vitamin D metabolism disorders, and phosphorus depletion is discussed. It is probable that many of them act together, causing reversible changes in muscular fibers. The intimate mechanisms of these changes are unknown.
骨软化性肌病较为罕见。然而，它们可能会流行，并在骨骼异常出现之前发生。由于组织病理学图像不具有特异性，诊断必须依靠临床观察。另一方面，在骨软化症期间，肌肉无力的表现非常常见。事实上，两种类型的表现对应于相同的解剖病理病变。在接受检查的10例患者的光学显微镜、组织酶学和超微结构检查中也观察到了这些肌病性改变。基于这些形态学变化，肌肉受累可被认为是骨软化症综合征的一部分。文中讨论了包括继发性甲状旁腺功能亢进、维生素D代谢紊乱和磷缺乏等各种因素的作用。它们中的许多因素可能共同起作用，导致肌纤维发生可逆性变化。这些变化的具体机制尚不清楚。
