Yoshikawa S, Nakamura T, Tanabe H, Imamura T
Endocrinol Jpn. 1979 Jun;26(Suppl):65-72. doi: 10.1507/endocrj1954.26.supplement_65.
Muscles from two cases of osteomalacia were studied histochemically and electron-microscopically. Histopathological finding were common in these two cases. There are (1) myopathic changes such as scattered muscle fiber atrophy, necrosis, and internal uuclei, (2) derangement of intermyofibrillar network. and (3) type II fiber atrophy. Electron-microscopical finding corresponded well with light microscopical findings. These are distinct pathological features and deserves to be called osteomalacic myopathy. As the pathogenetic mechanism of this myopathy, phosphate depletion in the muscle cells resulting in disturbed glycolysis, and decreased vitamin D effects on muscle cells resulting in diminished calcium uptake by sarcoplasmic reticulum, are considered to be the most important two factors.
对两例骨软化症患者的肌肉进行了组织化学和电子显微镜研究。这两例患者的组织病理学表现较为常见。包括：（1）肌病性改变，如散在的肌纤维萎缩、坏死及肌核内移；（2）肌原纤维间网络紊乱；（3）II型纤维萎缩。电子显微镜检查结果与光学显微镜检查结果相符。这些是明显的病理特征，值得称为骨软化性肌病。作为这种肌病的发病机制，肌肉细胞内磷酸盐缺乏导致糖酵解紊乱，以及维生素D对肌肉细胞的作用减弱导致肌浆网对钙的摄取减少，被认为是最重要的两个因素。
