Lester D
Center for the Study of Suicide, Blackwood, New Jersey, USA.
Pharmacopsychiatry. 1995 Mar;28(2):45-50. doi: 10.1055/s-2007-979587.
A review of 27 research reports on the cerebrospinal fluid levels of neurotransmitter metabolites involving 1202 psychiatric patients found strong evidence for the involvement of the serotonin system in suicidal behavior. Attempted suicides, especially those using violent methods, had lower levels of CSF 5-HIAA as compared to psychiatric controls, and those making subsequent suicidal actions also had lower levels of CSF 5-HIAA. The meta-analysis permitted more reliable conclusions to be drawn than did each individual study alone.
一项对涉及1202名精神科患者的27篇关于脑脊液神经递质代谢物水平的研究报告的综述发现，有强有力的证据表明血清素系统与自杀行为有关。与精神科对照相比，自杀未遂者，尤其是那些使用暴力手段的人，脑脊液5-羟吲哚乙酸（5-HIAA）水平较低，而那些随后采取自杀行动的人脑脊液5-HIAA水平也较低。荟萃分析比单独的每项研究能得出更可靠的结论。
