Higgins C F
Nuffield Department of Clinical Biochemistry, University of Oxford, John Radcliffe Hospital, UK.
J Bioenerg Biomembr. 1995 Feb;27(1):63-70. doi: 10.1007/BF02110332.
The multidrug resistance P-glycoprotein (P-gp) is an active drug transporter which can expel hydrophobic compounds from cells. Expression of P-gp has many effects on cells and tissues and the physiological function, or functions, of P-gp are still unclear. Recently, expression of P-gp has been associated with altered activity of chloride channels which play a role in regulating cell volume of response to osmotic shock or nutrient uptake. The nature and physiological role of this association has been a subject of some debate. In this article, mechanisms by which P-gp might influence cell volume-activated chloride currents is discussed, and the potential physiological role of this regulation considered.
多药耐药性P-糖蛋白（P-gp）是一种活性药物转运蛋白，可将疏水性化合物排出细胞。P-gp的表达对细胞和组织有多种影响，其生理功能仍不清楚。最近，P-gp的表达与氯离子通道活性的改变有关，氯离子通道在调节细胞对渗透压休克或营养物质摄取的反应中的细胞体积方面发挥作用。这种关联的性质和生理作用一直是一些争论的主题。在本文中，讨论了P-gp可能影响细胞体积激活氯离子电流的机制，并考虑了这种调节的潜在生理作用。
