Higgins C F
Nuffield Department of Clinical Biochemistry, University of Oxford, John Radcliffe Hospital.
J Physiol. 1995 Jan;482(P):31S-36S. doi: 10.1113/jphysiol.1995.sp020562.
The ability to regulate volume is an important property of most, if not all cells. In epithelial cells, amongst others, cell volume-activated chloride channels are central to this response. The molecular identities of these channels are not yet known. Expression of the human multidrug resistance P-glycoprotein (P-gp) has been associated with cell volume-regulated chloride currents, although the nature of this association is the subject of debate. Recent data indicate that P-gp acts by regulating the activation of an endogenous channel protein. In this review, evidence associating P-gp with cell volume-activated chloride currents, and the possible mechanisms by which this might be achieved, are discussed.
调节体积的能力是大多数（即便不是全部）细胞的一项重要特性。在众多细胞类型中，上皮细胞的细胞体积激活氯通道对于这种反应至关重要。这些通道的分子身份尚不清楚。人类多药耐药P-糖蛋白（P-gp）的表达与细胞体积调节氯电流有关，尽管这种关联的本质仍存在争议。最近的数据表明，P-gp通过调节内源性通道蛋白的激活来发挥作用。在这篇综述中，我们讨论了将P-gp与细胞体积激活氯电流相关联的证据，以及实现这种关联的可能机制。
