Cosenza M E, Bidanset J
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John's University, Jamaica, NY 11439, USA.
Vet Hum Toxicol. 1995 Apr;37(2):118-21.
Chlorpyrifos (CPF) is a broad-spectrum organophosphate insecticide used to control mosquitos and household insects. In man it has toxic effects on the central nervous system, the cardiovascular system and the respiratory system. This study investigated the toxicity of CPF on nervous system development using the midbrain micromass culture system. Chlorpyrifos was tested as a marketed formulation and in 3 solvents. All demonstrated toxicity in midbrain micromass cells with IC50 values below 30 ug/mL, indicating a potent teratogen.
毒死蜱（CPF）是一种用于控制蚊子和家庭害虫的广谱有机磷酸酯杀虫剂。对人类而言，它会对中枢神经系统、心血管系统和呼吸系统产生毒性作用。本研究使用中脑微团培养系统研究了毒死蜱对神经系统发育的毒性。毒死蜱以市售制剂形式并在3种溶剂中进行了测试。所有测试均表明其对中脑微团细胞具有毒性，半数抑制浓度（IC50）值低于30微克/毫升，表明它是一种强效致畸剂。
