经离子电泳施加的P物质可激活仓鼠视交叉上核神经元。

Ionophoretically applied substance P activates hamster suprachiasmatic nucleus neurons.

作者信息

Piggins H D, Cutler D J, Rusak B

机构信息

Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada.

出版信息

Brain Res Bull. 1995;37(5):475-9. doi: 10.1016/0361-9230(95)00027-c.

DOI:10.1016/0361-9230(95)00027-c

PMID:7543357

Abstract

ionophoretic ejection of substance P (SP) activated 31% and suppressed 9% of hamster suprachiasmatic nucleus (SCN) cells in vitro. Hamster SCN cells did not demonstrate variation in sensitivity to SP across the circadian phases tested. SP modulated the response of 47% of hamster SCN cells to the excitatory amino acid (EAA) agonists glutamate and N-methyl-D-aspartate (NMDA). The results indicate that SP can alter both the spontaneous and EAA-evoked firing rate characteristics of hamster SCN neurons.

摘要

在体外，离子电渗法注射P物质（SP）激活了31%的仓鼠视交叉上核（SCN）细胞，并抑制了9%的该细胞。在测试的昼夜节律阶段，仓鼠SCN细胞对SP的敏感性未表现出差异。SP调节了47%的仓鼠SCN细胞对兴奋性氨基酸（EAA）激动剂谷氨酸和N-甲基-D-天冬氨酸（NMDA）的反应。结果表明，SP可以改变仓鼠SCN神经元的自发放电率特性和EAA诱发的放电率特性。