Christiansen M, Høgdall C K, Brihmer C
Department of Clinical Biochemistry, Statens Seruminstitut, Copenhagen, Denmark.
Clin Chim Acta. 1995 Feb 28;235(1):71-9. doi: 10.1016/0009-8981(95)06002-5.
Alpha-fetoprotein (AFP) is used as a tumor marker for hepatomas and germ cell tumors. In healthy non-pregnant adults the serum concentration (S-AFP) is very low and we examined whether it was affected when the acute phase response was activated, using patients with acute pelvic inflammatory disease (PID) as a model system. In 70 PID patients the median S-AFP was 1.2 kIU/l (range: 0.5-5.9 kIU/l), within the normal range. S-AFP did not correlate with the clinical grade of disease nor with the serum concentrations of acute phase reactants and albumin. Thus, S-AFP is not significantly affected by activation of the acute phase response and presence of infection should not per se interfere with the use of S-AFP as a tumor marker. However, a negative correlation was found with the serum concentration of alpha-2-macroglobulin (P = 0.05), but whether this has any biological significance remains to be clarified.
甲胎蛋白（AFP）用作肝癌和生殖细胞瘤的肿瘤标志物。在健康的非妊娠成年人中，血清浓度（S-AFP）非常低，我们以急性盆腔炎（PID）患者作为模型系统，研究了急性期反应激活时S-AFP是否受到影响。70例PID患者的S-AFP中位数为1.2 kIU/l（范围：0.5 - 5.9 kIU/l），在正常范围内。S-AFP与疾病的临床分级以及急性期反应物和白蛋白的血清浓度均无相关性。因此，S-AFP不受急性期反应激活的显著影响，感染的存在本身不应干扰将S-AFP用作肿瘤标志物。然而，发现其与α-2-巨球蛋白的血清浓度呈负相关（P = 0.05），但这是否具有任何生物学意义仍有待阐明。
